Can Progesterone Make PMDD Worse? Understanding Hormone Sensitivity During Perimenopaus
When hormone therapy is supposed to help, but your mood symptoms seem to get worse instead. When I first started hormone replacement therapy (HRT) for perimenopause, I hoped it would help me feel more like myself again. I knew there might be an adjustment period. I understood that finding the right treatment could take time. But something happened that I wasn't expecting. For two consecutive menstrual cycles after starting HRT, my PMDD symptoms became worse. And if you've ever experienced PMDD, you know that worsening symptoms are no small thing. I started wondering whether the progesterone in my treatment might be contributing to how I was feeling. Was I experiencing progesterone intolerance? Was my body reacting to hormonal fluctuations? Or was perimenopause making my existing PMDD symptoms harder to manage? The more I researched, the more I realized that the relationship between progesterone, the brain, and emotional well-being is much more complicated than I originally un...